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Y. Xie et al.
ONCOGENE (2013)
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
Philip B. Verghese et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
MicroRNAs and neurodegeneration: role and impact
Masashi Abe et al.
TRENDS IN CELL BIOLOGY (2013)
Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
Dan Frenkel et al.
NATURE COMMUNICATIONS (2013)
Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging
Wandong Zhang et al.
FLUIDS AND BARRIERS OF THE CNS (2013)
miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling
Shanzhong Yang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
Gozde Korkmaz et al.
AUTOPHAGY (2012)
MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5
Xue-Mei Xu et al.
CANCER LETTERS (2012)
MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts
Hao Wu et al.
CELLULAR SIGNALLING (2012)
miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
Jaekwang Kim et al.
EXPERIMENTAL NEUROLOGY (2012)
MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7
Dongsheng Sun et al.
FEBS LETTERS (2012)
Impact of microRNA regulation on variation in human gene expression
Jian Lu et al.
GENOME RESEARCH (2012)
ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide (1-40) at the Mouse Blood-Brain Barrier
Tuan Minh Do et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease
Rashid Deane et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice
Nicholas F. Fitz et al.
JOURNAL OF NEUROSCIENCE (2012)
PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice
Mitsugu Yamanaka et al.
JOURNAL OF NEUROSCIENCE (2012)
microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
Huanyu Zhang et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer
Junqing Chen et al.
MEDICAL ONCOLOGY (2012)
Review: Unchained maladie - a reassessment of the role of Ubb+1-capped polyubiquitin chains in Alzheimer's disease
L. Chadwick et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2012)
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Jeffrey J. Iliff et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Dun-Sheng Yang et al.
BRAIN (2011)
The Role of Tau in Alzheimer's Disease and Related Disorders
Rodrigo Medeiros et al.
CNS NEUROSCIENCE & THERAPEUTICS (2011)
Comparison of mRNA Expression Patterns of Class B Scavenger Receptors in BV2 Microglia upon Exposure to Amyloidogenic Fragments of Beta-Amyloid and Prion Proteins
Mohammed Kouadir et al.
DNA AND CELL BIOLOGY (2011)
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes
Arash Haghikia et al.
EUROPEAN HEART JOURNAL (2011)
MicroRNA-29b Suppresses Tumor Angiogenesis, Invasion, and Metastasis by Regulating Matrix Metalloproteinase 2 Expression
Jian-Hong Fang et al.
HEPATOLOGY (2011)
MicroRNA-155 regulates lipid uptake, adhesion/chemokine marker secretion and SCG2 expression in oxLDL-stimulated dendritic cells/macrophages
Ting Chen et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2011)
Cholesterol and Amyloid-beta: Evidence for a Cross-Talk between Astrocytes and Neuronal Cells
Elisa Canepa et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
Min Song et al.
JOURNAL OF NEUROINFLAMMATION (2011)
Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice
Tatsuya Hoshino et al.
JOURNAL OF NEUROSCIENCE (2011)
Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease
Alaa H. Abuznait et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Mechanism mediating oligomeric Aβ clearance by naive primary microglia
Cheng-Ning Yang et al.
NEUROBIOLOGY OF DISEASE (2011)
MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II
Jian Xiao et al.
JOURNAL OF BIOMEDICAL SCIENCE (2011)
Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP) in Vitro
Mei-Chen Liao et al.
BIOCHEMISTRY (2010)
Mammalian autophagy: core molecular machinery and signaling regulation
Zhifen Yang et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1
Bjoern von Einem et al.
EXPERIMENTAL NEUROLOGY (2010)
Apical-to-Basolateral Transport of Amyloid-beta Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein
Pietra Candela et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly
Mei-Chen Liao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid beta-peptide elimination from the brain
Berislav V. Zlokovic et al.
JOURNAL OF NEUROCHEMISTRY (2010)
ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer's disease
Shanshan Shen et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model
Kalliopi Thanopoulou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Assembly, structure, and function of the 26S proteasome
Lynn Bedford et al.
TRENDS IN CELL BIOLOGY (2010)
MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1
Heesang Song et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-Brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition
Laura B. Jaeger et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Degradation of Amyloid β Protein by Purified Myelin Basic Protein
Mei-Chen Liao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
Anne Simonsen et al.
JOURNAL OF CELL BIOLOGY (2009)
Cell-derived soluble oligomers of human amyloid-beta peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons
Ting-Ting Yang et al.
JOURNAL OF NEURAL TRANSMISSION (2009)
ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for Aβ1-40 Peptides
Huaqi Xiong et al.
JOURNAL OF NEUROSCIENCE (2009)
The Small Heat Shock Protein Hsp27 Protects Cortical Neurons Against the Toxic Effects of β-Amyloid Peptide
Michael King et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells
Yu-Zhuo Pan et al.
MOLECULAR PHARMACOLOGY (2009)
Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
Jungsu Kim et al.
NEURON (2009)
Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice
Stefanie Frank et al.
NEUROSCIENCE LETTERS (2009)
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction
Kazuhiro Takuma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain
Yoshinari Uehara et al.
BRAIN RESEARCH (2008)
apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain
Rashid Deane et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
Barry Boland et al.
JOURNAL OF NEUROSCIENCE (2008)
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid β1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
Karine L. Richard et al.
JOURNAL OF NEUROSCIENCE (2008)
ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier
Shin-Ichi Akanuma et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease
Binggui Sun et al.
NEURON (2008)
Cerebral clearance of human amyloid-β peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes
Shingo Ito et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Clearance of amyloid-β by circulating lipoprotein receptors
Abhay Sagare et al.
NATURE MEDICINE (2007)
Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system
Robert D. Bell et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)
Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains
Lori-Ann Christie et al.
NEUROBIOLOGY OF DISEASE (2007)
The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment
M. Giunta et al.
NEUROBIOLOGY OF AGING (2007)
Inhibition of familial cerebral amyloid angiopathy mutant amyloid β-protein fibril assembly by myelin basic protein
Michael D. Hoos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Aluminum inhibits proteolytic degradation of amyloid β peptide by cathepsin D:: A potential link between aluminum accumulation and neuritic plaque deposition
Takashi Sakamoto et al.
FEBS LETTERS (2006)
Heat shock proteins 70 and 90 inhibit early stages of amyloid β-(1-42) aggregation in vitro
Christopher G. Evans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Role of toll-like receptor signalling in Aβ uptake and clearance
Kazuki Tahara et al.
BRAIN (2006)
Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver
Chihiro Tamaki et al.
PHARMACEUTICAL RESEARCH (2006)
Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo
Randall J. Bateman et al.
NATURE MEDICINE (2006)
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
Stewart H. Lecker et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Small heat shock proteins inhibit amyloid-β protein aggregation and cerebrovascular amyloid-β protein toxicity
Micha M. M. Wilhelmus et al.
BRAIN RESEARCH (2006)
β-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
CG Almeida et al.
JOURNAL OF NEUROSCIENCE (2006)
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
V Hirsch-Reinshagen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
R Koldamova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease
SE Wahrle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A genomic and functional inventory of deubiquitinating enzymes
SMB Nijman et al.
CELL (2005)
Amyloid β-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor
ML Hemming et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model
JR Cirrito et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients
M Fiala et al.
JOURNAL OF ALZHEIMERS DISEASE (2005)
The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide
R Oba et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
RA Nixon et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed β-amyloid in neurons
J Magrané et al.
JOURNAL OF NEUROSCIENCE (2004)
Systemic catabolism of Alzheimer's Aβ40 and Aβ42
J Ghiso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The Role of P-glycoprotein in Cerebral Amyloid Angiopathy; Implications for the Early Pathogenesis of Alzheimer's Disease
Silke Vogelgesang et al.
CURRENT ALZHEIMER RESEARCH (2004)
Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
H Kanemitsu et al.
NEUROSCIENCE LETTERS (2003)
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
H Osaka et al.
HUMAN MOLECULAR GENETICS (2003)
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
R Deane et al.
NATURE MEDICINE (2003)
Heat shock protein-90-induced microglial clearance of exogenous amyloid-β1-42 in rat hippocampus in vivo
K Takata et al.
NEUROSCIENCE LETTERS (2003)
CD36 mediates the innate host response to β-amyloid
JB El Khoury et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Relationship between β-amyloid degradation and the 26S proteasome in neural cells
ML Salon et al.
EXPERIMENTAL NEUROLOGY (2003)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Scavenger receptor class B type I expression and elemental analysis in cerebellum and parietal cortex regions of the Alzheimer's disease brain
RAK Srivastava et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2002)
Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins
J Kakimura et al.
FASEB JOURNAL (2002)
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
IS Coraci et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide (Aβ);: Retards Aβ aggregation, deposition, fibril formation, and inhibits cytotoxicity.
JG Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
RB DeMattos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Metabolic regulation of brain Aβ by neprilysin
N Iwata et al.
SCIENCE (2001)
Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid
J Husemann et al.
JOURNAL OF NEUROIMMUNOLOGY (2001)
Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
M Shibata et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma:: Suppression leads to biochemical and pathological deposition
N Iwata et al.
NATURE MEDICINE (2000)
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