4.7 Article

Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

A novel class of anthraquinone-based HDAC6 inhibitors

Yoojin Song et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class Ha histone deacetylase inhibitor

Christopher A. Luckhurst et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Article Chemistry, Medicinal

Design and biological evaluation of tetrahydro-beta-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors

Michel Leonhardt et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies

Margherita Brindisi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Histone Deacetylase Inhibitors as Anticancer Drugs

Tomas Eckschlager et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Multidisciplinary Sciences

Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors

Nicholas J. Porter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Multidisciplinary

HDAC6 Brain Mapping with [18F] Bavarostat Enabled by a RuMediated Deoxyfluorination

Martin G. Strebl et al.

ACS CENTRAL SCIENCE (2017)

Article Multidisciplinary Sciences

Histone/protein deacetylase 11 targeting promotes Foxp3+Treg function

Jianbing Huang et al.

SCIENTIFIC REPORTS (2017)

Article Chemistry, Medicinal

Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class Ila Histone Deacetylase (HDAC) Inhibitors

Christopher A. Luckhurst et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Article Chemistry, Medicinal

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

Balaram Ghosh et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Multidisciplinary Sciences

A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates

K. Rajasekhar et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors

Laura Goracci et al.

SCIENTIFIC REPORTS (2016)

Review Medicine, General & Internal

Development of chidamide for peripheral T-cell lymphoma, the first orphan drug approved in China

Xianping Lu et al.

INTRACTABLE & RARE DISEASES RESEARCH (2016)

Article Biochemistry & Molecular Biology

Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors

Young Jun Seo et al.

ACS CHEMICAL NEUROSCIENCE (2014)

Article Oncology

Benzothiazoles: How Relevant in Cancer Drug Design Strategy?

Meenakshi Singh et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2014)

Article Cell Biology

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

Edward Seto et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Review Chemistry, Organic

Amyloid-β probes: Review of structure-activity and brain-kinetics relationships

Todd J. Eckroat et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2013)

Article Multidisciplinary Sciences

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

Melissa Malvaez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biotechnology & Applied Microbiology

Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma

Karen M. VanderMolen et al.

JOURNAL OF ANTIBIOTICS (2011)

Review Biochemistry & Molecular Biology

Small organic probes as amyloid specific ligands - Past and recent molecular scaffolds

K. Peter R. Nilsson

FEBS LETTERS (2009)

Review Biotechnology & Applied Microbiology

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

Aleksey G. Kazantsev et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Review Oncology

The role of histone deacetylases (HDACs) in human cancer

Santiago Ropero et al.

MOLECULAR ONCOLOGY (2007)

Review Chemistry, Medicinal

Structure-brain exposure relationships

Stephen A. Hitchcock et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Biochemical Research Methods

Clonogenic assay of cells in vitro

Nicolaas A. P. Franken et al.

NATURE PROTOCOLS (2006)

Review Genetics & Heredity

Acetylation and deacetylation of non-histone proteins

MA Glozak et al.

Article Chemistry, Medicinal

High throughput artificial membrane permeability assay for blood-brain barrier

L Di et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)