Journal
NUTRIENTS
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nu11102517
Keywords
Alaska Pollock; peptide; intestinal mucosal immune; SIgA; purification
Categories
Funding
- National Key R&D Program of China [2018YFC0311200]
- National Natural Science Foundation of China [31772046]
- Key Research & Development Plan of Shandong Province [2017YYSP015]
Ask authors/readers for more resources
The intestinal mucosal barrier plays an important role in systemic immune functions. This study aimed to find the mechanism of peptide from Alaska Pollock (APP) on intestinal mucosal immunity in mice induced by cyclophosphamide (Cy). Cy-induced decreases of body weight and index of immune organ were significantly improved by APP as compared with Cy group (p < 0.05). APP could promote the secretion of SIgA and IgA on intestinal mucosa (p < 0.05) and mainly had an impact on the final differentiation of IgA(+) B cell, thereby promoting the secretion of plasma cells, which can be corroborated by the increases of IL-6 and IL-10 (p < 0.05). APP with high immune activity was separated and two peptides were purified and identified as Gly-Val-Ile-Lys and Ala-Cys-Asn-Gly-Arg. Therefore, APP can be considered as beneficial ingredients to protect the intestinal barrier disruption induced by Cy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available