4.6 Review

Vibrational Spectroscopy Fingerprinting in Medicine: from Molecular to Clinical Practice

Journal

MATERIALS
Volume 12, Issue 18, Pages -

Publisher

MDPI
DOI: 10.3390/ma12182884

Keywords

fourier transform infrared spectroscopy; Raman spectroscopy; ex vivo; in vivo; clinic; fingerprint

Funding

  1. Ministry of Research and Innovation, CNCS-UEFISCDI [PN-III-P1-1.1-PD-2016-1642]

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In the last two decades, Fourier Transform Infrared (FTIR) and Raman spectroscopies turn out to be valuable tools, capable of providing fingerprint-type information on the composition and structural conformation of specific molecular species. Vibrational spectroscopy's multiple features, namely highly sensitive to changes at the molecular level, noninvasive, nondestructive, reagent-free, and waste-free analysis, illustrate the potential in biomedical field. In light of this, the current work features recent data and major trends in spectroscopic analyses going from in vivo measurements up to ex vivo extracted and processed materials. The ability to offer insights into the structural variations underpinning pathogenesis of diseases could provide a platform for disease diagnosis and therapy effectiveness evaluation as a future standard clinical tool.

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