Journal
BIOPHYSICAL JOURNAL
Volume 109, Issue 3, Pages 461-468Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2015.06.050
Keywords
-
Categories
Funding
- Engineering and Physical Sciences Research Council [1094646] Funding Source: researchfish
Ask authors/readers for more resources
In the following review we use recent examples from the literature to discuss progress in the area of atomistic and coarse-grained molecular dynamics simulations of selected bacterial membranes and proteins, with a particular focus on Gramnegative bacteria. As structural biology continues to provide increasingly high-resolution data on the proteins that reside within these membranes, simulations have an important role to play in linking these data with the dynamical behavior and function of these proteins. In particular, in the last few years there has been significant progress in addressing the issue of biochemical complexity of bacterial membranes such that the heterogeneity of the lipid and protein components of these membranes are now being incorporated into molecular-level models. Thus, in future we can look forward to complementary data from structural biology and molecular simulations combining to provide key details of structure-dynamics-function relationships in bacterial membranes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available