Journal
HUMAN FERTILITY
Volume 24, Issue 5, Pages 367-375Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14647273.2019.1673906
Keywords
Thin endometrium; tocopherol; pentoxifylline; endometrial volume; implantation failure; recurrent pregnancy loss
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The study aimed to analyze whether treatment with a combination of pentoxifylline and tocopherol could increase endometrial volume in patients with poor endometrial development. The findings revealed that this combination therapy significantly increased endometrial volume.
Poor endometrial development during in vitro fertilization remains challenging. Indeed, no broadly accepted definition of poor endometrial development exists, and no treatment has shown any improvement in the condition. The aim of this study was to analyze whether treatment with a combination of pentoxifylline and tocopherol increases endometrial volume. This monocentric and retrospective study includes patients with previous miscarriages, in vitro fertilization failure, or poor endometrial development. The patients had an ultrasonography during the mid-luteal phase to assess both endometrial thickness and endometrial volume (EV). If the volume was less than 2?mL, they were given pentoxifylline (PTX) and tocopherol for at least 2 months before a second ultrasound assessment. One hundred and forty-four patients were analyzed. The mean duration of treatment was 132 days. The combination of tocopherol and PTX significantly increased the EV by 0.47?mL (p?
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