Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-12373-5
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Funding
- Juvenile Diabetes Research Foundation [1-PNF-2018-522-S-B]
- National Institutes of Health (NIH) [1R01DK105967-01A1]
- Novo Nordisk Company
- American Diabetes Association [7-13-JF-42]
- 3M Company
- SUNY Research Foundation
- NSF Materials Research Science and Engineering Centers (MRSEC) program [NSF DMR-1120296]
- National Science Foundation [ECCS-1542081]
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The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development of a broadly applicable strategy for stable and functional vascularization has remained challenging. We report here highly organized and resilient microvascular meshes fabricated through a controllable anchored self-assembly method. The microvascular meshes are scalable to centimeters, almost free of defects and transferrable to diverse substrates, ready for transplantation. They promote formation of functional blood vessels, with a density as high as similar to 220 vessels mm(-2), in the poorly vascularized subcutaneous space of SCID-Beige mice. We further demonstrate the feasibility of fabricating microvascular meshes from human induced pluripotent stem cell-derived endothelial cells, opening a way to engineer patient-specific microvasculature. As a proof-of-concept for type 1 diabetes treatment, we combine microvascular meshes and subcutaneously transplanted rat islets and achieve correction of chemically induced diabetes in SCID-Beige mice for 3 months.
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