Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-12253-y
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Funding
- SciLifeLab
- national infrastructure SNISS, and Uppmax
- Knut and Alice Wallenberg Foundation
- Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- King's College London
- King's College Hospital NHS Foundation Trust [guysbrc-2012-1]
- Dunhill Medical Trust
- Association pour la Recherche contre le Cancer (ARC)
- European Research Council [IT-DC 281987]
- Institute National de la Sante et de la Recherche Medicale [BIO2012-02, BIO2014-08]
- INCA [2011-1-PL BIO-12-IC-1]
- Fondation ARSEP [R12023JJ]
- ANR [ANR-13-BSV1-0024-02, ANR-10-IDEX-0001-02 PSL*, ANR11-LABX-0043, 114021503]
- BIOMAP IMI2 [821511]
- [261366]
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV1-0024] Funding Source: Agence Nationale de la Recherche (ANR)
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Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.
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