Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-13250-x
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Funding
- European Research Council under the European Union's Horizon 2020 research and innovation program (BISON, Advanced ERC grant) [694426]
- Planning and Budget Committee, Israel
- National Natural Science Foundation of China [11804148, 11804147]
- National Institute of General Medical Sciences from the National Institutes of Health [P30 GM124165]
- NIH-ORIP HEI grant [S10 RR029205]
- DOE Office of Science [DE-AC02-06CH11357]
- National Key Research and Development Program of China [2016YFA0501702]
- National Science Foundation of China [11674065]
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The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit their application. Here, we combine the advantages of polyamide materials and the structural patterns inspired by nucleic-acids to generate a mechanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology and photoluminescent properties. The assembly possesses a unique atomic structure, with each guanine head of one molecule hydrogen bonded to the Fmoc carbonyl tail of another molecule, generating a non-planar cyclic quartet arrangement. This structure exhibits an average stiffness of 69.6 +/- 6.8 Nm(-1) and Young's modulus of 17.8 +/- 2.5 GPa, higher than any previously reported nucleic acid derived structure. This data suggests that the unique cation-free basket formed by the Fmoc-G-PNA conjugate can serve as an attractive component for the design of new materials based on PNA self-assembly for nanotechnology applications.
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