Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-12134-4
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Funding
- NSF project Energy-and Cost-Efficient Manufacturing Employing Nanoparticles [NSF 1463474]
- NSF [DMR-9871177, 1566460, 1538180]
- National Natural Science Foundation of China [21631005, 21673104, 21522102, 21503095]
- MURI: Department of Army [W911NF-10-1-0518]
- AFOSR [FA9550-16-1-0265, UM 088163]
- National Science Foundation [ACI-1532235, ACI-1532236]
- DOE Office of Science User Facility [DE-AC02-06CH11357]
- DMREF/Collaborative Research: Design and Testing of Nanoalloy Catalysts in 3D Atomic Resolution [DMREF 1623947]
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Nanoscale biological assemblies exemplified by exosomes, endosomes and capsids, play crucial roles in all living systems. Supraparticles (SP) from inorganic nanoparticles (NPs) replicate structural characteristics of these bioassemblies, but it is unknown whether they can mimic their biochemical functions. Here, we show that chiral ZnS NPs self-assemble into 70-100 nm SPs that display sub-nanoscale porosity associated with interstitial spaces between constituent NPs. Similarly to photosynthetic bacterial organelles, these SPs can serve as photocatalysts, enantioselectively converting L- or D-tyrosine (Tyr) into dityrosine (diTyr). Experimental data and molecular dynamic simulations indicate that the chiral bias of the photocatalytic reaction is associated with the chiral environment of interstitial spaces and preferential partitioning of enantiomers into SPs, which can be further enhanced by co-assembling ZnS with Au NPs. Besides replicating a specific function of biological nanoassemblies, these findings establish a path to enantioselective oxidative coupling of phenols for biomedical and other needs.
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