Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-12873-4
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Funding
- Erasmus Medical Center, Rotterdam
- Netherlands Organization for the Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- Netherlands Society for Scientific Research (NWO) VIDI Grant [917103521]
- Erasmus MC mRACE grant Profiling of the human gut microbiome
- ERC [715772]
- NWO-VIDI [016.136.367, 016.178.056, 864.13.013]
- CardioVasculair Onderzoek Nederland [CVON 2012-03]
- Graduate School of Medical Sciences, University of Groningen
- Erasmus University, Rotterdam
- European Research Council (ERC) [715772] Funding Source: European Research Council (ERC)
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Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.
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