Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-13115-3
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Funding
- National Natural Science Foundation of China [81771836, 81501473, 81671695, 81601502, 81725008]
- Fostering Project of Shanghai Municipal Commission of Health and Family Planning for Excellent Young Medical Scholars [2018YQ31]
- Shanghai Science and Technology Committee Rising-Star Program [19QA1406800]
- Opening Project of Guangxi Key Laboratory of Bio-targeting Theranostics [GXSWBX201801]
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201811SIC]
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Despite the efficacy of current starvation therapies, they are often associated with some intrinsic drawbacks such as poor persistence, facile tumor metastasis and recurrence. Herein, we establish an extravascular gelation shrinkage-derived internal stress strategy for squeezing and narrowing blood vessels, occluding blood & nutrition supply, reducing vascular density, inducing hypoxia and apoptosis and eventually realizing starvation therapy of malignancies. To this end, a biocompatible composite hydrogel consisting of gold nanorods (GNRs) and thermal-sensitive hydrogel mixture was engineered, wherein GRNs can strengthen the structural property of hydrogel mixture and enable robust gelation shrinkage-induced internal stresses. Systematic experiments demonstrate that this starvation therapy can suppress the growths of PANC-1 pancreatic cancer and 4T1 breast cancer. More significantly, this starvation strategy can suppress tumor metastasis and tumor recurrence via reducing vascular density and blood supply and occluding tumor migration passages, which thus provides a promising avenue to comprehensive cancer therapy.
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