Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-11829-y
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Funding
- National Natural Science Foundation of China [81571763, 81622026, 61425006, 81871401]
- Shanghai Jiao Tong University [YG2016MS51, YG2017MS54]
- State Key Laboratory of Oncogenes and Related Genes [91-17-28]
- Shanghai Key Laboratory of Gynecologic Oncology, Guangci Professorship Program of Ruijin Hospital
- Shanghai Municipal Education Commission [ZXWF082101]
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Surface-enhanced Raman spectroscopy (SERS) is advantageous over fluorescence for bioimaging due to ultra-narrow linewidth of the fingerprint spectrum and weak photo-bleaching effect. However, the existing SERS imaging speed lags far behind practical needs, mainly limited by Raman signals of SERS nanoprobes. In this work, we report ultrabright gap-enhanced Raman tags (GERTs) with strong electromagnetic hot spots from interior sub-nanometer gaps and external petal-like shell structures, larger immobilization surface area, and Raman cross section of reporter molecules. These GERTs reach a Raman enhancement factor beyond 5 x 10(9) and a detection sensitivity down to a single-nanoparticle level. We use a 370 mu W laser to realize high-resolution cell imaging within 6 s and high-contrast (a signal-to-background ratio of 80) wide-area (3.2 x 2.8 cm(2)) sentinel lymph node imaging within 52 s. These nanoprobes offer a potential solution to overcome the current bottleneck in the field of SERS-based bioimaging.
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