Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-12046-3
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Funding
- German Center for Infection Research (DZIF) Thematic Translational Unit HIV-1 04.704 Infrastructural Measure
- Hector Grant M70 HiPNose: HiV Positioning in the Nuclear Space
- Spanish Ministry of Economy and Competitiveness (Centro de Excelencia Severo Ochoa 2013-2017, Plan Nacional) [BFU2012-37168]
- CERCA (Centres de Recerca de Catalunya) Programme/Generalitat de Catalunya
- European Research Council [609989]
- European Structural and Investment Funds [KK.01.1.1.01.0010, KK.01.1.1.01.0009, IP-2014-09-6400]
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HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4(+) T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for HIV-1 integration have so far remained unclear. Here we show that recurrently targeted genes are proximal to super-enhancer genomic elements and that they cluster in specific spatial compartments of the T cell nucleus. We further show that these gene clusters acquire their location during the activation of T cells. The clustering of these genes along with their transcriptional activity are the major determinants of HIV-1 integration in T cells. Our results provide evidence of the relevance of the spatial compartmentalization of the genome for HIV-1 integration, thus further strengthening the role of nuclear architecture in viral infection.
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