Journal
ONCOLOGY LETTERS
Volume 18, Issue 6, Pages 6379-6384Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2019.11039
Keywords
prostate cancer; benign prostatic hyperplasia; long non-coding RNA NCK1 antisense RNA 1; transforming growth factor-beta 1
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Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown. It was revealed in the present study that plasma NCK1-AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Upregulation of NCK1-AS1 distinguished patients with PC from patients with BPH and healthy controls. Overexpression of NCK1-AS1 led to significantly upregulated transforming growth factor (TGF)-beta 1, while TGF-beta 1 overexpression failed to significantly affect NCK1-AS1 in PC cells. NCK1-AS1 overexpression led to promoted migration and invasion. TGF-beta inhibitor played an opposite role and attenuated the effects of NCK1-AS1 overexpression. Therefore, NCK1-AS1 may upregulate TGF-beta 1 to promote PC.
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