Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 64, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2019.103595
Keywords
Catalase; Copper; Cyclooxygenase; Fish oil; Nitric oxide; Pinacidil
Categories
Ask authors/readers for more resources
Cardiovascular alterations can be improved by the long-term use of fish oil (FO), as well as an adequate supply of copper (Cu). Recently, copper nanoparticles (CuNPs), as an alternative to ionic forms (CuCO3) were found to decrease the level of protein/DNA oxidation. Male Wistar rats were supplemented for 8 weeks with FO (7 g/kg) together with 40 nm sized CuNPs and CuCO3 (6.5 mg Cu/kg). FO with CuNPs modified the superoxide dismutase, catalase, and decreased Cu concentration in the blood. Meanwhile noradrenaline-induced contraction of an isolated aorta was not altered, but acetylcholine-induced vasodilation was reduced. FO with CuCO3 increased the antioxidant capacity of blood, and Zn concentration, however decreased the level of triglycerides. Noradrenaline-induced contraction was improved with no change in acetylcholine-induced response. Since the modifications induced by the FO-supplemented diet corresponded with different Cu formulations, the interaction between FO and CuNPs may follow the replacement of CuCO3 with CuNPs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available