Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 64, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2019.103584
Keywords
Corn germ meal; ACE inhibitory peptide; Enzymatic membrane reactor; Gradient diafiltration feeding working-mode; In vivo antihypertensive effect
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Funding
- National Key Research and Development Program of China [YFD0400303-1, 2016]
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This study investigated the performance of an enzymatic membrane reactor (EMR) with a new gradient diafiltration feeding (GDF) working-mode on the production of peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity from corn germ meal (CGM) under the selected conditions. The antihypertensive effect of the released peptide was evaluated in vivo. Results showed that the protein conversion rate and the peptide yield were 81.94% and 80.20%, respectively, when the EMR-GDF worked for 660 min, and the corresponding IC50 value of the released peptide was 0.83 mg/mL. In vivo experimental results indicated that the high-dose corn germ peptide significantly reduced the systolic blood pressure (SBP) by 18.22 and 28.6 mmHg in acute oral and long-term intragastric administration tests, respectively. The corn germ peptide could also inhibit the ACE activities in kidney, lung, and heart of rats and regulate the level of endothelium-derived vasoconstrictor and relaxing factors in serum.
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