4.6 Review

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Estimating the global incidence of traumatic brain injury

Michael C. Dewan et al.

JOURNAL OF NEUROSURGERY (2019)

Article Neurosciences

Mesenchymal stem cell therapy for the treatment of traumatic brain injury: progress and prospects

Mahasweta Das et al.

REVIEWS IN THE NEUROSCIENCES (2019)

Article Clinical Neurology

First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury

Klaus Kucher et al.

NEUROREHABILITATION AND NEURAL REPAIR (2018)

Review Cell Biology

Emerging potential of exosomes for treatment of traumatic brain injury

Ye Xiong et al.

NEURAL REGENERATION RESEARCH (2017)

Review Pharmacology & Pharmacy

Cell-Penetrating Peptides: From Basic Research to Clinics

Giulia Guidotti et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Multidisciplinary Sciences

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Raffaele Simeoli et al.

NATURE COMMUNICATIONS (2017)

Article Engineering, Biomedical

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

Dongfen Yuan et al.

BIOMATERIALS (2017)

Article Multidisciplinary Sciences

Chromatographically isolated CD63+ CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

Dong-ki Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Chemistry, Multidisciplinary

Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases

Claudia Saraiva et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Editorial Material Pharmacology & Pharmacy

Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases

Michael Chopp et al.

EXPERT OPINION ON EMERGING DRUGS (2015)

Article Biochemistry & Molecular Biology

Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice

Ke Ding et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

Review Biology

Exosome platform for diagnosis and monitoring of traumatic brain injury

Douglas D. Taylor et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Review Pharmacology & Pharmacy

Minocycline: far beyond an antibiotic

N. Garrido-Mesa et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Review Cell Biology

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

Anja Schneider et al.

CELL AND TISSUE RESEARCH (2013)

Article Pharmacology & Pharmacy

Rho as a Target to Promote Repair: Translation to Clinical Studies with Cethrin

Lisa McKerracher et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Article Transplantation

Autologous Bone Marrow Mesenchymal Stem Cell Therapy in the Subacute Stage of Traumatic Brain Injury by Lumbar Puncture

Chunlei Tian et al.

EXPERIMENTAL AND CLINICAL TRANSPLANTATION (2013)

Article Critical Care Medicine

Analysis of Recruitment and Outcomes in the Phase I/IIa Cethrin Clinical Trial for Acute Spinal Cord Injury

Lisa McKerracher et al.

JOURNAL OF NEUROTRAUMA (2013)

Article Multidisciplinary Sciences

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

Marcel Grapp et al.

NATURE COMMUNICATIONS (2013)

Article Clinical Neurology

C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury

Stefanie C. Huelsenbeck et al.

NEUROTHERAPEUTICS (2012)

Review Biochemistry & Molecular Biology

Cell-penetrating peptides: breaking through to the other side

Erez Koren et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Review Pharmacology & Pharmacy

Altered calcium signaling following traumatic brain injury

John T. Weber

FRONTIERS IN PHARMACOLOGY (2012)

Article Clinical Neurology

Acute Minocycline Treatment Mitigates the Symptoms of Mild Blast-Induced Traumatic Brain Injury

Erzsebet Kovesdi et al.

Frontiers in Neurology (2012)

Article Anesthesiology

Traumatic brain injury in modern war

Geoffrey S. F. Ling et al.

CURRENT OPINION IN ANESTHESIOLOGY (2011)

Article Critical Care Medicine

Therapeutic Window Analysis of the Neuroprotective Effects of Cyclosporine A after Traumatic Brain Injury

Patrick G. Sullivan et al.

JOURNAL OF NEUROTRAUMA (2011)

Article Critical Care Medicine

Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

Michael G. Fehlings et al.

JOURNAL OF NEUROTRAUMA (2011)

Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

Review Biology

Traumatic brain injury

Jane E. Risdall et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

Article Neurosciences

Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury

Layla T. Galindo et al.

NEUROLOGY RESEARCH INTERNATIONAL (2011)

Review Cell Biology

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

Teuntje M. J. C. Andriessen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)

Review Endocrinology & Metabolism

Traumatic brain injury: an overview of pathobiology with emphasis on military populations

Ibolja Cernak et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)

Article Endocrinology & Metabolism

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice

Bridgette D. Semple et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)

Article Endocrinology & Metabolism

Vascular endothelial growth factor increases neurogenesis after traumatic brain injury

Orli Thau-Zuchman et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)

Article Clinical Neurology

Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury

Roukoz Chamoun et al.

JOURNAL OF NEUROSURGERY (2010)

Article Critical Care Medicine

Post-Traumatic Hypoxia Exacerbates Brain Tissue Damage: Analysis of Axonal Injury and Glial Responses

Sarah C. Hellewell et al.

JOURNAL OF NEUROTRAUMA (2010)

Article Critical Care Medicine

In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury

Tony Frugier et al.

JOURNAL OF NEUROTRAUMA (2010)

Review Clinical Neurology

Clinical Trials in Traumatic Brain Injury: Past Experience and Current Developments

Andrew I. R. Maas et al.

NEUROTHERAPEUTICS (2010)

Review Clinical Neurology

Cell Death Mechanisms and Modulation in Traumatic Brain Injury

Bogdan A. Stoica et al.

NEUROTHERAPEUTICS (2010)

Article Pharmacology & Pharmacy

Brain Drug Delivery System: An Overview

Pushpanjali C. Ligade et al.

CURRENT DRUG THERAPY (2010)

Review Chemistry, Medicinal

Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain

Xanthi Antoniou et al.

PHARMACEUTICALS (2010)

Review Biochemistry & Molecular Biology

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Giles E. Hardingham

BIOCHEMICAL SOCIETY TRANSACTIONS (2009)

Article Endocrinology & Metabolism

Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury

Lamin Han Mbye et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Clinical Neurology

Long-term Neurologic Outcomes After Traumatic Brain Injury

Jeffrey J. Bazarian et al.

JOURNAL OF HEAD TRAUMA REHABILITATION (2009)

Article Neurosciences

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

Helene Girouard et al.

JOURNAL OF NEUROSCIENCE (2009)

Review Neurosciences

Central Nervous System Regeneration Inhibitors and their Intracellular Substrates

Michelle Nash et al.

MOLECULAR NEUROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

Calpain Inhibition Reduces Axolemmal Leakage in Traumatic Axonal Injury

Endre Czeiter et al.

MOLECULES (2009)

Review Neurosciences

Biomaterials for promoting brain protection, repair and regeneration

Gorka Orive et al.

NATURE REVIEWS NEUROSCIENCE (2009)

Article Clinical Neurology

Erythropoietin as a neuroprotective agent in traumatic brain injury Review

Antonios Mammis et al.

SURGICAL NEUROLOGY (2009)

Article Critical Care Medicine

NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade

Kwok-Tung Lu et al.

CRITICAL CARE MEDICINE (2008)

Review Pharmacology & Pharmacy

Neuroprotection in traumatic brain injury

K. K. Jain

DRUG DISCOVERY TODAY (2008)

Article Neurosciences

Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia

Radmila Fillpovic et al.

EXPERIMENTAL NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury

Mubeen A. Ansari et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Clinical Neurology

Prevalence of Long-Term Disability From Traumatic Brain Injury in the Civilian Population of the United States, 2005

Eduard Zaloshnja et al.

JOURNAL OF HEAD TRAUMA REHABILITATION (2008)

Review Critical Care Medicine

A time course of contusion-induced oxidative stress and synaptic proteins in cortex in a rat model of TBI

Mubeen A. Ansari et al.

JOURNAL OF NEUROTRAUMA (2008)

Review Critical Care Medicine

Classification of traumatic brain injury for targeted therapies

Kathryn E. Saatman et al.

JOURNAL OF NEUROTRAUMA (2008)

Review Chemistry, Medicinal

Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms

M. L. Houchin et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Review Multidisciplinary Sciences

Autophagy fights disease through cellular self-digestion

Noboru Mizushima et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain

Rachel Lin et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Review Pharmacology & Pharmacy

Cell-penetrating peptides for drug delivery across membrane barriers

Camilla Foged et al.

EXPERT OPINION ON DRUG DELIVERY (2008)

Review Critical Care Medicine

Modulation of immune response by head injury

Maria Cristina Morganti-Kossmann et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2007)

Review Cell Biology

Autophagy: process and function

Noboru Mizushima

GENES & DEVELOPMENT (2007)

Article Critical Care Medicine

Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury

Kumi Nagamoto-Combs et al.

JOURNAL OF NEUROTRAUMA (2007)

Article Pharmacology & Pharmacy

Neuroprotection with erythropoietin administration following controlled cortical impact injury in rats

Leela Cherian et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Review Endocrinology & Metabolism

Myelin-associated inhibitory signaling and strategies to overcome inhibition

Nagarathnamma Chaudhry et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Biochemistry & Molecular Biology

Role of the mitochondrial membrane permeability transition in cell death

Yoshihide Tsujimoto et al.

APOPTOSIS (2007)

Article Neurosciences

Rapamycin is a neuroprotective treatment for traumatic brain injury

S. Erlich et al.

NEUROBIOLOGY OF DISEASE (2007)

Article Chemistry, Multidisciplinary

Effect of excipients on PLGA film degradation and the stability of an incorporated peptide

M. L. Houchin et al.

JOURNAL OF CONTROLLED RELEASE (2007)

Review Cell Biology

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Critical Care Medicine

Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury

Frank K. H. Van Landeghem et al.

JOURNAL OF NEUROTRAUMA (2006)

Article Clinical Neurology

Military TBI during the Iraq and Afghanistan wars

Deborab Warden

JOURNAL OF HEAD TRAUMA REHABILITATION (2006)

Review Pharmacology & Pharmacy

Therapeutic potential of controlled drug delivery systems in neurodegenerative diseases

N. Popovic et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

Article Neurosciences

Activation of Rho after traumatic brain injury and seizure in rats

CI Dubreuil et al.

EXPERIMENTAL NEUROLOGY (2006)

Review Critical Care Medicine

Overcoming inhibition in the damaged spinal cord

JW Fawcett

JOURNAL OF NEUROTRAUMA (2006)

Review Clinical Neurology

All roads lead to disconnection?: Traumatic axonal injury revisited

A Büki et al.

ACTA NEUROCHIRURGICA (2006)

Article Critical Care Medicine

Closed head injury induces upregulation of Beclin 1 at the cortical site of injury

T Diskin et al.

JOURNAL OF NEUROTRAUMA (2005)

Review Pharmacology & Pharmacy

Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

B Gupta et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

Article Neurosciences

A novel pathway for presynaptic mitogen-activated kinase activation via AMPA receptors

U Schenk et al.

JOURNAL OF NEUROSCIENCE (2005)

Article Neurosciences

Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death?

PG Sullivan et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

Review Clinical Neurology

Cell death mechanisms following traumatic brain

R Raghupathi

BRAIN PATHOLOGY (2004)

Article Neurosciences

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

S Mi et al.

NATURE NEUROSCIENCE (2004)

Article Endocrinology & Metabolism

Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury

SM Knoblach et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)

Article Cell Biology

Mitochondrial damage and dysfunction in traumatic brain injury

J Lifshitz et al.

MITOCHONDRION (2004)

Article Medicine, Legal

Long-term intracerebral inflammatory response after traumatic brain injury

SM Gentleman et al.

FORENSIC SCIENCE INTERNATIONAL (2004)

Article Critical Care Medicine

Lesional expression of RhoA and RhoB following traumatic brain injury in humans

C Brabeck et al.

JOURNAL OF NEUROTRAUMA (2004)

Article Clinical Neurology

Diffuse axonal injury in head trauma

DH Smith et al.

JOURNAL OF HEAD TRAUMA REHABILITATION (2003)

Article Biochemistry & Molecular Biology

Caspase-8 expression and proteolysis in human brain after severe head injury

XP Zhang et al.

FASEB JOURNAL (2003)

Article Critical Care Medicine

Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat

R Raghupathi et al.

JOURNAL OF NEUROTRAUMA (2003)

Review Neurosciences

Semaphorin junction: making tracks toward neural connectivity

RJ Pasterkamp et al.

CURRENT OPINION IN NEUROBIOLOGY (2003)

Review Clinical Neurology

The epidemiology of traumatic brain injury: A review

TJ Bruns et al.

EPILEPSIA (2003)

Article Endocrinology & Metabolism

Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice

KE Saatman et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2003)

Article Multidisciplinary Sciences

p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

KC Wang et al.

NATURE (2002)

Article Critical Care Medicine

Both MK801 and NBQX reduce the neuronal damage after impact-acceleration brain injury

M Goda et al.

JOURNAL OF NEUROTRAUMA (2002)

Article Neurosciences

Cytochrome c release and caspase activation after traumatic brain injury

PG Sullivan et al.

BRAIN RESEARCH (2002)

Article Engineering, Biomedical

Electrospun nanofibrous structure: A novel scaffold for tissue engineering

WJ Li et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)

Article Neurosciences

Injury-induced class 3 semaphorin expression in the rat spinal cord

F De Winter et al.

EXPERIMENTAL NEUROLOGY (2002)

Article Multidisciplinary Sciences

Chondroitinase ABC promotes functional recovery after spinal cord injury

EJ Bradbury et al.

NATURE (2002)

Article Endocrinology & Metabolism

Mitogen-activated protein kinase inhibition in traumatic brain injury:: In vitro and in vivo effects

T Mori et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)

Article Biochemistry & Molecular Biology

Local and systemic increase in lipid peroxidation after moderate experimental traumatic brain injury

D Pratico et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Review Chemistry, Multidisciplinary

Biodegradable polymeric nanoparticles as drug delivery devices

KS Soppimath et al.

JOURNAL OF CONTROLLED RELEASE (2001)

Article Multidisciplinary Sciences

Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury

ML Brines et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Neurosciences

Adult bone marrow stromal cells differentiate into neural cells in vitro

J Sanchez-Ramos et al.

EXPERIMENTAL NEUROLOGY (2000)

Article Biochemistry & Molecular Biology

Bioavailability of Ziconotide in brain: influx from blood, stability, and diffusion

R Newcomb et al.

PEPTIDES (2000)

Article Nutrition & Dietetics

Glutamate as a neurotransmitter in the brain: Review of physiology and pathology

BS Meldrum

JOURNAL OF NUTRITION (2000)

Article Biochemistry & Molecular Biology

Caspase-3 mediated neuronal death after traumatic brain injury in rats

RSB Clark et al.

JOURNAL OF NEUROCHEMISTRY (2000)

Review Pharmacology & Pharmacy

Cell-penetrating peptides

M Lindgren et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2000)