Journal
BIOTECHNOLOGY JOURNAL
Volume 12, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201600104
Keywords
Constraint-based modeling; Metabolic switch; Oleaginous microorganisms; Omics; Systems biology
Funding
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HN12C0055]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2014K1A3A1A20034749]
- NRF [NRF-2012H1A2A1001956]
- National Research Foundation of Korea [2012H1A2A1001956, 2014K1A3A1A20034749] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Heterotrophic oleaginous microorganisms continue to draw interest as they can accumulate a large amount of lipids which is a promising feedstock for the production of biofuels and oleochemicals. Nutrient limitation, especially nitrogen limitation, is known to effectively trigger the lipid production in these microorganisms. For the aim of developing improved strains, the mechanisms behind the lipid production have been studied for a long time. Nowadays, system-level understanding of their metabolism and associated metabolic switches is attainable with modern systems biology tools. This work reviews the systems biology studies, based on (i) topdown, large-scale 'omics' tools, and (ii) bottom-up, mathematical modeling methods, on the heterotrophic oleaginous microorganisms with an emphasis on further application to metabolic engineering.
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