Journal
TRENDS IN PARASITOLOGY
Volume 35, Issue 10, Pages 778-794Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2019.07.012
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Funding
- Israel-US Binational Science Foundation (BSF)
- Icore program of the Planning and budgeting committee
- Israel Science Foundation [1796/12]
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Trypanosomatids are protozoan parasites that cycle between an insect and a mammalian host. The large-subunit rRNA of these organisms undergoes unique processing events absent in other eukaryotes. Recently, small nucleolar RNAs (snoRNAs) that mediate these specific cleavages were identified. Trypanosomatid rRNA is rich in RNA modifications such as 2'-O-methylation (Nm) and pseudouridylation (Psi) that are also guided by these snoRNAs. A subset of these modifications is developmentally regulated and increased in the parasite form that propagates in the mammalian host. Such hypermodification contributes the temperature adaptation and hence infectivity during cycling of the parasite. rRNA processing and modification should be considered promising drug targets for fighting the diseases caused by these parasites.
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