Journal
TRENDS IN MOLECULAR MEDICINE
Volume 26, Issue 2, Pages 215-231Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2019.09.006
Keywords
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Funding
- National Institutes of Health (NICHD) [R01 HD056034]
- National Natural Science Foundation of China [81730042]
- Science and Technology Department of Zhejiang Province [2019C03035]
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Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which takes place in the epithelium of seminiferous tubules. Sertoli cells, also known as 'mother' or 'nurse' cells, provide nutrients, paracrine factors, cytokines, and other biomolecules to support gear cell development. Sertoli cells facilitate the generation of several biologically active peptides, which include F5-, noncoflagenous 1 (NC1)-, and laminin globular (LG)3/4/5-peptide, to modulate cellular events across the epithelium. Here, we critically evaluate the involvement of these pep tides in facilitating crosstalk between Sertoli and germ cells to support spermatogenesis anc thus fertility. Modulating or mimicking the activity of F5-, NC1-, and LG3/4/5-peptide could be used to enhance the transport across the blood-testis barrier (BTB) of contraceptive drugs of to treat male infertility.
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