Journal
TRENDS IN MOLECULAR MEDICINE
Volume 26, Issue 2, Pages 185-200Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2019.09.007
Keywords
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Funding
- American Diabetes Association [1-13-JF-53, 1-11-BS-017, 1-15-BS-018]
- NSFC [81770305, 91639111, 81573435, 81273509, 30971209]
- Foundation for Distinguished Young Scholars of Sichuan Province [2019JDJQ0042]
- Innovative Team Project of Chengdu Medical College [CYTD17-01]
- Fund of Development and Regeneration Key Laboratory of Sichuan Province [SYS18-04]
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Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic cells and functions to induce a broad range of defenses against exogenous and endogenous stresses, including oxidants, xenobiotics, and excessive nutrient/metabolite supply. Because the production and fate of stem cells are often r d by cellular redox and metabolic homeostasis, important roles of Nrf2 have emerged in the regulation of stem cell quiescence, survival, self renewal, proliferation, senescence, and differentiation. In a rapidly advancing field, this review summarizes Nrf2 signaling in the context of stem cell state and function and provides a rationale for Nrf2 as a therapeutic target in stem cell-based regenerative medicine.
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