Journal
TRENDS IN MOLECULAR MEDICINE
Volume 26, Issue 1, Pages 71-88Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2019.10.009
Keywords
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Funding
- European Research Council (ERC) [Stg 337327]
- Deutsche Forschungsgemeinschaft [SFB1190-P02]
- Fundacao para a Ciencia e a Tecnologia (FCT) Portugal [SFRH/BD/100341/2014]
- Montepio Foundation [CPD0028001]
- European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme [CENTRO-07-ST24-FEDER-002008]
- European Regional Development Fund (ERDF), through the COMPETE 2020 Operational Programme for Competitiveness and Internationalisation
- Portuguese national funds via the FCT [PTDC/BIA-MOL/28607/2017, POCI-01-0145FEDER-028607, PTDC/BTM-SAL/29297/2017, POCI-01-0145-FEDER-02929, PTDC/MED-FAR/29391/2017, POCI-01-0145-FEDER-029391, UID/NEU/04539/2019]
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Cellular function requires coordination between different organelles and metabolic cues. Mitochondria and lysosomes are essential for cellular metabolism as major contributors of chemical energy and building blocks. It is therefore pivotal for cellular function to coordinate the metabolic roles of mitochondria and lysosomes. However, these organelles do more than metabolism, given their function as fundamental signaling platforms in the cell that regulate many key pro cesses such as autophagy, proliferation, and cell death. Mechanisms of crosstalk between mitochondria and lysosomes are discussed, both under physiological conditions and in diseases that affect these organelles.
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