Journal
TRENDS IN MICROBIOLOGY
Volume 28, Issue 3, Pages 212-223Publisher
CELL PRESS
DOI: 10.1016/j.tim.2019.10.009
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Funding
- Heilongjiang Province Natural Science Foundation [C2016068]
- State Key Laboratory of Veterinary Biotechnology Foundation [SKLVBP2018002]
- China Scholarship Council [201703250019]
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Porcine reproductive and respiratory syndrome virus (PRRSV) dramatically affects the thymus and its ability to carry out its normal functions. In particular, infection incapacitates PRRSV-susceptible CD14(pos) antigen-presenting cells (APCs) in the thymus and throughout the body. PRRSV-induced autophagy in thymic epithelial cells modulates the development of T cells, and PRRSV-induced apoptosis in CD4(pos)CD8(pos) thymocytes modulates cellular immunity against PRRSV and other pathogens. Pigs are less able to resist and/or eliminate secondary infectious agents due the effect of PRRSV on the thymus, and this susceptibility phenomenon is long recognized as a primary characteristic of PRRSV infection.
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