Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 10, Pages 888-908Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.08.003
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Funding
- National Institutes of Health (NIH) [HD097531]
- Canadian Institutes of Health Research (CIHR) [PJT-148821]
- Canada Research Chair
- Anna Maria Solinas Laroche Career Award in Immunology
- NIH [HD097531]
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During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance. In response to infection, immunogenic DCs promote the generation of proinflammatory effector T cell subsets. When complex homeostatic mechanisms maintaining the balance between regulatory and effector functions become impaired, autoimmune diseases can develop. We discus! some of the newest advances on the mechanisms of physiopathologic homeostasis that can be employed to develop strategies to restore a dysregulated immune equilibrium. Some of these designs are based on selectively activating regulators of immunity and inflammation instead of broadly suppressing these processes. Promising approaches include the use of nanoparticles (NPs) to restore Treg control over self-reactive cells, aiming to achieve long-term disease remission, and potentially to prevent autoimmunity in susceptible individuals.
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