Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 10, Pages 952-973Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.08.007
Keywords
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Categories
Funding
- Defense Threat Reduction Agency (DTRA) [HDTRA1-15-1-0050, HDTRA1-14-1-0007]
- Leona M. and Harry B. Helmsley Charitable Trust [3239]
- National Institutes of Health (NIH) [229825, 4-R33-AI121669-04]
- Pfizer Incorporated [8500437439]
- U.S. Army Medical Research and Material Command [W81XWH-16-1-0565, W81XWH-17-1-0159, W81XWH-18-1-0513]
- Space and Naval Warfare Systems Center [N66001-13-C-4025]
- Defense Advanced Research Projects Agency (DARPA) [152304.5106735.0006, HR0011-15-C-0084]
- National Science Foundation (NSF) [CCF-1521925, DMR-1419807]
- Army Research Office [W911NF-17-2-0077]
- ARO-ISN UARC [W911NF-13-D-0001 T. O. 8]
- American Heart Association [229460]
- Human Frontier Science Program [LT000595/2017-L]
- Singapore-MIT Alliance for Research and Technology (S.M.A.R.T.)
- Breast Cancer Alliance
- United States-Israel Binational Science Foundation [2017189]
- Amyotrophic Lateral Sclerosis Association [18-IIA-403]
- MIT Science and Technology Initiatives (MISTI) - Spain La Caixa [2244102]
- Pew Charitable Trusts [00030623]
- Defense Threat Reduction Agency (DTRA via George Mason University) [E2045481]
Ask authors/readers for more resources
The gut microbiome has a significant impact on health and disease and can actively contribute to obesity, diabetes, inflammatory bowel disease, cardiovascular disease, and neurological disorders. We do not yet have the necessary tools to fine-tune the microbial communities that constitute the microbiome, though such tools could unlock extensive benefits to human health. Here , we provide an overview of the current state of technological tools that may be used for microbiome engineering. These tools can enable investigators to define the parameters of a health microbiome and to determine how gut bacteria may contribute to the etiology of a variety of diseases. These tools may also allow us to explore the exciting prospect of developing targeted therapies and personalized treatments for microbiome-linked diseases.
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