Journal
BIOTECHNOLOGY ADVANCES
Volume 34, Issue 3, Pages 250-271Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.10.005
Keywords
Hydrogels; In vitro diagnostics; Photonic crystals; Inverse opals; Holography; Bragg stacks; Crystalline colloidal arrays; Block copolymers; Layer-by-layer deposition; Plasmonics
Categories
Funding
- National Institutes of Health [P41EB015903]
- National Science Foundation [ECCS-1505569, CBET-264356]
- Department of Defence [FA9550-11-1-0331]
- Bio & Medical Technology Development Program [2012M3A9C6049791]
- IT Consilience Creative Program [NIPA-2014-H0201-14-1001]
- Marie Curie International Outgoing Fellowship [627274]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1505569] Funding Source: National Science Foundation
- National Research Foundation of Korea [2012M3A9C6049791] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, and continuous measurement capability that can be integrated with equipment-free text or image display. This Review explains the operation principles of photonic hydrogel sensors, presents syntheses of stimuli-responsive polymers, and provides an overview of qualitative and quantitative readout technologies. Applications in clinical samples are discussed, and potential future directions are identified. (C) 2015 Elsevier Inc. All rights reserved.
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