Journal
BIOTECHNOLOGY ADVANCES
Volume 34, Issue 5, Pages 803-812Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2016.04.005
Keywords
Hypoxia; Targeted therapy; HIF-1; pH targeted; Solid tumor microenvironment; Physicochemical change
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Funding
- NIH [EB018575]
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh
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In recent years, there has been great progress in the understanding of tumor biology and its surrounding micro environment. Solid tumors create regions with low oxygen levels, generally termed as hypoxic regions. These hypoxic areas offer a tremendous opportunity to develop targeted therapies. Hypoxia is not a random by-product of the cellular milieu due to uncontrolled tumor growth; rather it is a constantly evolving participant in overall tumor growth and fate. This article reviews current trends and recent advances in drug therapies and delivery systems targeting hypoxia in the tumor microenvironment. In the first part, we give an account of important physicochemical changes and signaling pathways activated in the hypoxic microenvironment. This is then followed by various treatment strategies including hypoxia-sensitive signaling pathways and approaches to develop hypoxia-targeted drug delivery systems. Published by Elsevier Inc.
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