4.5 Article

Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended triazoles

Journal

TOXICOLOGY IN VITRO
Volume 60, Issue -, Pages 87-96

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2019.05.009

Keywords

Pyrimidine-Pyrrole scaffold; Triazole; Synthesis; Anti-cancer activity; Molecular docking

Categories

Funding

  1. SERB DST [EMR/2016/001411]

Ask authors/readers for more resources

The new pyrimidine-pyrrole scaffolds (7a-7m) with substituted 1,2,3-traizole moiety were synthesized in good to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have been discussed.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available