Journal
TALANTA
Volume 209, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2019.120516
Keywords
Gemini-iridium complex; Isoniazide; Mitochondria-targeted; Hypochlorite anion; Chemo-sensor
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Funding
- National Natural Science Foundation of China [21676057, 51903050]
- Fourth Health Education Joint Development Project of Fujian Province [WKJ2016-2-04]
- Research Program for Young and Middle-Aged Teachers of Fujian Province [JT180039]
- Natural Science Foundation of Fujian Province [2019J01258]
- Opening Foundation from Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology [ACEMT-17-02]
- Opening Project of State Key Laboratory of Polymer Materials Engineering (Sichuan University) [sklpme2019-4-34]
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Monitoring hypochlorite anion (ClO-) in living cells is particularly meaningful and valuable, because overexposure of the ClO- may cause a potential health hazard towards animals and humans. Considering the special structure and properties of the gemini surfactant, a novel amphiphilic gemini-iridium complex Ir[(ppy-iso)(2)(bpy-tma(2)Br(2))] (Ir-iso) with isoniazide as a recognition site for ClO- was designed. The Ir-iso possessed an excellent water-solubility as well as a strong ClO- binding capacity, as revealed from the rapid response of emission signal towards ClO-. It was worth noting that such probe had a highly-specific selectivity with a low detection limit (20.5 nM) and was suitable in physiological environment. The cell viability assay, cell imaging, and co-location studies further proved that the Ir-iso had little cytotoxicity and was specifically localized in the mitochondria of breast cancer cells, being a promising candidate of chemo-sensor to detect the endogenous ClO- in living cells.
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