Journal
TALANTA
Volume 204, Issue -, Pages 431-437Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2019.06.032
Keywords
Imaging; Fluorescent probe; Peroxynitrite; Living cells; Drug-induced liver injury
Categories
Funding
- Natural Science Foundation of Jiangsu Province [BK20181331]
- Double First-Class University project [CPU2018GY38, CPU2018GY24]
- National Natural Science Foundation of China [NSFC 81671745]
- Qinglan Project of Jiangsu Province (2018)
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Peroxynitrite anion (ONOO-), one of the reactive nitrogen species (RNS), plays momentous roles in physiological and pathological processes especially in a range of oxidative stress-related diseases. Moreover, abundant ONOO- is generated in the liver tissues of drug-induced liver injury. We report herein a novel small molecule fluorescent probe KC-ONOO for monitoring ONOO- based on boronate. The probe displayed high sensitivity and good selectivity towards ONOO-. A good linear relationship was observed between the fluorescent intensity at 530 nm and the concentration of ONOO- ranged 0-10 mu M with a detection limit of 1.5 x 10(-8) M. Furthermore, our probe was successfully applied for imaging ONOO- in living cells and drug-damaged liver tissues with low cytotoxicity, demonstrating the probe KC-ONOO has great potential to further elucidate more biological roles of ONOO-.
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