4.4 Article

Catalytic Asymmetric Synthesis of Atropisomeric Quinolines through the Friedlander Reaction

Journal

SYNLETT
Volume 30, Issue 19, Pages 2198-2202

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0039-1690228

Keywords

Friedlander reaction; atroposelectivity; quinolines; phosphoric acids; acetylacetone

Funding

  1. National Natural Science Foundation of China (NSFC) [21573161, 21571144]
  2. Natural Science Foundation of Zhejiang Province [LY18B020011, LQ19B020004]
  3. Foundation of Wenzhou Basic Scientific Research Project [G20180015]

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A phosphoric acid catalyzed atroposelective Friedlander reaction was developed in which acetylacetone and a variety of 2'-substituted 2-aminobenzophenones were successfully employed to give optically active biaryl quinolines in good yields and with high enantioselectivities.

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