Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 228, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.117798
Keywords
Raman spectrophotometer; Instrumentation; Wide area illumination; Low-frequency; Pharmaceutical products
Categories
Funding
- Instituto Nacional de Ciencia e Tecnologia Analiticas AVancadas/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (INCTAA/CNPq) [465768/2014-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/50951-4]
- IQ-Unicamp-Instituto de QUimica da Unicamp/Grupo de Instrumentacao e Automacao (IQ-Unicamp/GIA)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- CAPES [88887.195518/2018-00 INCT]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/50951-4] Funding Source: FAPESP
Ask authors/readers for more resources
This work describes an optical configuration for a Raman spectrophotometer, which permits variation of the laser spot size from 3 to 3000 mu m, maintaining a high Raman photons throughput and allowing acquisitions with a short integration time. In addition, the instrument can acquire spectra from the low to middle frequency vibrational range (10 to 2000 cm(-1)), on the Stokes and anti-Stokes sides. One of the features of this new optical configuration is the non-use of beam splitters to redirect the scattered light to the detector, which would sacrifice the laser power. The quantitative and qualitative analytical performances of the Raman spectrophotometer were evaluated using chemometric models to predict the concentrations of different active pharmaceutical ingredients (APIs) in mixtures with polymorphs and excipients, as well as by analysis of an API mixture employing hyperspectral imaging. This new optical configuration was shown to be versatile for pharmaceutical purposes and could be used in applications such as the characterization of new drugs or the quality control of raw materials and processes, using normal Raman measurements or SERS (surface-enhanced Raman scattering). (c) 2019 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available