4.7 Article

A novel 'turn-on' coumarin-based fluorescence probe with aggregation-induced emission (AIE) for sensitive detection of hydrazine and its imaging in living cells

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.117272

Keywords

Aggregation induced emission (AIE); Cell imaging; Fluorescent turn-on probe; Hydrazine N2H4; Intramolecular charge transfer (ICT)

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Funding

  1. National Natural Science Foundation of China [21001040]
  2. Joint Program for Fostering Talents of National Natural Science Foundation of China and Henan Province [U1304202, U1604124]
  3. Science and Technology Department of Henan Province [182300410183, 162300410011, 162300410236, 152102210343]
  4. Education Department of Henan Province [19A150001, 15B150016, 15HASTIT002]
  5. Foundation of Henan Polytechnic University [T2018-3, J2015-4]

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An aggregation-induced emission (AIE)- and intramolecular charge transfer (ICT)-based probe 1 (7 hydroxy 3 (3 methyl isoxazol 5 yl) chromen 2 one) that is highly selective for N2H4 has been synthesized, exhibiting a 'turn-on' response toward N2H4 in CH3CN/H2O solution. The detection limit of the probe was 2.90 ppb, whichwas evidently lower than the threshold limit value (10 ppb) recommended by the Environmental Protection Agency. Notably, the sensor could be used for the detection of N2H4 in living cells. (C) 2019 Published by Elsevier B.V.

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