Journal
BIOSENSORS & BIOELECTRONICS
Volume 77, Issue -, Pages 774-789Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.10.032
Keywords
Point of care testing; Microfluidics; Paper; Biochemical; Immunological; Molecular
Categories
Funding
- National Natural Science Foundation of China [81472831, 61201033]
- Medical Key Talent Foundation of Jiangsu Province [RC2011081]
- Medical Key Science and Technology Development Projects of Nanjing [ZKX11176]
- Talents Planning of Six Summit Fields of Jiangsu Province [2013-WSN-054, 2013-WSN-056]
- Science and Technology Development Fund of Nanjing Medical University [2014NJMU138]
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Paper is increasingly recognized as a user-friendly and ubiquitous substrate for construction of microfluidic devices. Microfluidic paper-based analytical devices (mu PADs) provide an alternative technology for development of affordable, portable, disposable and low-cost diagnostic tools for improving point of care testing (POCT) and disease screening in the developing world, especially in those countries with no- or low-infrastructure and limited trained medical and health professionals. We in this review present fabrication techniques for microfluidic devices and their respective applications for biological detection as reported to date. These include: (i) fabrication techniques: examples of devices fabricated by using two-dimensional (2D) and three-dimensional (3D) methods; (ii) detection application: biochemical, immunological and molecular detection by incorporating efficient detection methods such as, colorimetric detection, electrochemical detection, fluorescence detection, chemiluminescence (CL) detection, electrochemiluninescence (ECL) detection, photoelectrochemi (PEC) detection and so on. In addition, main advantages, disadvantages and future trends for the devices are also discussed in this review. (C) 2015 Elsevier B.V. All rights reserved.
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