Journal
SMALL
Volume 15, Issue 49, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201904979
Keywords
electrospinning; nanoparticles; oesophageal stents; photodynamic therapy; tumor hypoxia
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Funding
- National Nature Science Foundation of China [81571773, 81771943, 51873107, 81971714]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grants [20152528, 20171906]
- Shanghai Jiao Tong University Medical and Research Program [ZH2018ZDA04, ZH2018ZDA19]
- Shanghai Talent Development Fund [2018099]
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Drug-eluting stents (DESs) are promising candidates for treating human oesophageal cancer. However, the use of DESs to assist photodynamic therapy (PDT) of orthotopic oesophageal tumors is not yet demonstrated to the best of current knowledge. Herein, through an electrospinning technology it is shown that oxygen-producing manganese dioxide nanoparticles are embedded into elelctrospun fibers, which are subsequently covered onto stents. Upon implantation, the nanoparticles are gradually released from the fibers and then diffuse into the nearby tumor tissue. Then, the hypoxic microenvironment can be effectively alleviated by reaction of MnO2 with the endogenous H2O2 within the tumor. After demonstrating the excellent PDT efficacy of the stents in a conventional subcutaneous mouse tumor model, such stents are further used for PDT treatment in a rabbit orthotopic oesophageal cancer model by inserting an optical fiber into the tumor site. Greatly prolonged survival of rabbits is observed after such intraluminal PDT treatment. Taken together, this work shows that the fiber-covered stent as a nanoparticle delivery platform can enable effective PDT as a noninvasive treatment method for patients with advanced-stage oesophageal cancer.
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