Effect of maternal sleep in late pregnancy on leptin and lipid levels in umbilical cord blood

Objectives: To study the impact of maternal sleep in late pregnancy on birth weight (BW) and leptin and lipid levels in umbilical cord blood. Study design: A total of 277 healthy and singleton pregnancy women were recruited for participation in the Shanghai Sleep Birth Cohort Study (SSBC) during their 36-38 weeks of pregnancy, from May 2012 to July 2013. Maternal night sleep time (NST), sleep efficiency (SE), sleep onset latency (SOL) and the percentage of wake after sleep onset (WASO) in NST and midpoint of sleep (MSF) were measured by actigraphy for seven consecutive days. The leptin and lipid levels were determined in cord blood samples collected from the umbilical vein immediately after delivery. Birth information (birth weight, gender, delivery type, etc.) was extracted from medical records. A multivariable linear regression model was applied to examine the effect of maternal sleep in late pregnancy on newborn leptin and lipid levels in umbilical cord blood. Results: A total of 177 women and their infants were included in the analysis. Maternal mean NST was 7.03 +/- 1.10 h in late pregnancy, and 48% had a shorter sleep time (NST < 7 h). The average maternal SE was 72.54% +/- 9.66%. The mean percentage WASO/NST was 21.62% +/- 9.98%; the average MSF was about 3:34 (0:53); and the SOL was 46.78 +/- 36.00 min. After adjustment for confounders, both maternal NST and SE were found to be significantly associated with triglyceride levels (beta = -0.219, p = 0.006; beta = -0.224, p = 0.006) in umbilical cord blood; and maternal NST was also observed to have positive association with newborn leptin levels (beta = 0.146, p = 0.047). However, we did not find significant association between other maternal sleep parameters in late pregnancy and leptin and lipid levels and birth weight. Conclusions: Short sleep duration and poor sleep quality during late pregnancy were associated with newborn leptin and lipid levels, and efforts on improving maternal sleep during late pregnancy should be advocated for children's health. (C) 2019 Published by Elsevier B.V.

Automated summary

The study found that maternal sleep duration and sleep efficiency in late pregnancy were significantly associated with newborn triglyceride levels in umbilical cord blood, and sleep duration was also positively correlated with newborn leptin levels. However, no significant association was found between other maternal sleep parameters in late pregnancy and birth weight, leptin, and lipid levels.