Journal
SLEEP MEDICINE
Volume 75, Issue -, Pages 50-53Publisher
ELSEVIER
DOI: 10.1016/j.sleep.2019.09.018
Keywords
ADHD; High-density EEG; Slow-wave activity; Development; Sensitive period maturation; Local sleep
Categories
Funding
- Swiss National Science Foundation [PPOOA-114923]
- Clinical Research Priority Program (CRPP) Sleep and Health of the University of Zurich, Switzerland
- HMZ Flagship Project SleepLoop of the University Medicine Zurich, Switzerland
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Objective/Background: Learning of a visuomotor adaptation task during wakefulness leads to a local in-crease in slow-wave activity (SWA, EEG power between 1 and 4.5 Hz) during subsequent deep sleep. Here, we examined this relationship between learning and SWA in children with attention-deficit/ hyperactivity disorder (ADHD). Patients/Methods: Participants were 15 children with ADHD (9.7-14.8 y, one female) and 15 age matched healthy controls (9.6-15.7 y, three female). After the completion of a visuomotor adaptation task in the evening, participants underwent an all-night high-density (HD, 128 electrodes) sleep-EEG measurement. Results: Healthy control children showed the expected right-parietal increase in sleep SWA after visuomotor learning. Despite no difference in visuomotor learning, the local up-regulation during sleep was significantly reduced in ADHD patients compared to healthy controls. Conclusions: Our results indicate that the local, experience-dependent regulation of SWA is different in ADHD patients. Because the customarily observed heightened regulation in children was related to sensitive period maturation, ADHD patients may lack certain sensitive periods or show a developmental delay. (c) 2019 Elsevier B.V. All rights reserved.
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