4.6 Review

Overview of the Evolution of Silica-Based Chromo-Fluorogenic Nanosensors

Journal

SENSORS
Volume 19, Issue 23, Pages -

Publisher

MDPI
DOI: 10.3390/s19235138

Keywords

nanoparticles; silica; mesoporous; color; fluorescence; sensor; molecular recognition; arrays; gated materials

Funding

  1. Spanish Government [RTI2018-100910-B-C41, RTI2018-100910-B-C44, AGL2015-70235-C2-2-R]
  2. Generalitat Valenciana [PROMETEO/2018/024]
  3. Spanish MEC

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This review includes examples of silica-based, chromo-fluorogenic nanosensors with the aim of illustrating the evolution of the discipline in recent decades through relevant research developed in our group. Examples have been grouped according to the sensing strategies. A clear evolution from simply functionalized materials to new protocols involving molecular gates and the use of highly selective biomolecules such as antibodies and oligonucleotides is reported. Some final examples related to the evolution of chromogenic arrays and the possible use of nanoparticles to communicate with other nanoparticles or cells are also included. A total of 64 articles have been summarized, highlighting different sensing mechanisms.

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