Journal
SEMINARS IN NEUROLOGY
Volume 39, Issue 5, Pages 589-595Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0039-1693005
Keywords
Guillain-Barre syndrome; acute inflammatory demyelinating polyneuropathy; acute motor axonal polyneuropathy; Miller-Fisher syndrome
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Guillain-Barre syndrome (GBS) is the leading cause of acute paralysis that can potentially affect all of the human population. GBS is believed to be an immune-mediated disease, possibly triggered by a recent infection, and driven by an immune attack targeting the peripheral nervous system. GBS can be divided into several subtypes depending on the phenotype, pathophysiology, and neurophysiological features. Unfortunately, morbidity and mortality rates are still high despite the current understanding of the pathophysiology and available treatment options. Additional research is still needed to shed more light into the pathogenesis for a better understanding and treatment of this condition.
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