Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 41, Issue 6, Pages 757-766Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-019-00767-y
Keywords
Inflammation; Lipoxygenase; Resolvins; Vascular injury
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Funding
- Karolinska Institute
- Swedish Heart and Lung Foundation [20180571, 20180572, 20170311]
- King Gustaf V and Queen Victoria Freemason Foundation
- Stockholm County Council [20170365]
- Marianne and Marcus Wallenberg Foundation [2015.0104]
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Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory response. The proresolving lipid mediator resolvin E1 (RvE1) is formed by enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA), and signals resolution of inflammation through its receptor ChemR23. Importantly, the resolution of cardiovascular inflammation is an active, multifactorial process that involves modulation of the immune response, direct actions on the vascular wall, as well as close interactions between macrophages and vascular smooth muscle cells. Promoting anti-atherogenic signalling through the stimulation of endogenous resolution of inflammation pathways may provide a novel therapeutic strategy in cardiovascular prevention.
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