Journal
SEMINARS IN IMMUNOLOGY
Volume 44, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2019.101325
Keywords
Tumour immunology; Pegylated IL-10; CD8 T cell cytotoxicity; T cell invigoration clinical trial
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The expansion and activation of tumor antigen reactive CD8(+) T cells are primary goals of immunotherapies for cancer. IL-10 is an anti-inflammatory cytokine with an essential role in the development and proliferation of regulatory T cells, restricting myeloid and chronic inflammatory T cell responses. However, IL-10 is also essential for the expansion of antigen activated, tumor specific CD8(+) T cells, leading to spontaneous tumor development in IL-10 deficient patients and mice. IL-10 induces IFN gamma and cytotoxic mediators in antigen activated T cells. In clinical trials, monotherapy with recombinant, pegylated IL-10 (Pegilodecakin) induced objective responses in cancer patients. Patients receiving pegilodecakin had a systemic increase of IFN gamma and granzymes, proliferation and expansion of immune checkpoint positive CD8(+) T cells. Combination of pegilodecakin with anti-PD-1 appeared to improve on the efficacy of the single agents.
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