Journal
BIOSENSORS & BIOELECTRONICS
Volume 85, Issue -, Pages 515-521Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.05.029
Keywords
Self-assembled; Turn-on; Fluorescence; Zinc; BODIPY
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Funding
- National Natural Science Foundation of China [21321064]
- Instrument Developing Project of the Chinese Academy of Sciences [50502]
- Chinese Academy of Sciences (100 Talents Program)
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Zinc plays important roles in regulating physiological and pathological processes. Regrettably, mild to moderate zinc deficiency is common worldwide. Hair Zn2+ concentration, which reflects a zinc storage status, is useful for tracking trends in zinc status within populations. In this work, we report BODIPY-based self-assembled nanoparticles (NPs) as fluorescence turn-on sensor for the selective sensing of Zn2+ in human hair. The BODIPY monomers (BAN) self-assemble in aqueous medium to form non fluorescent NPs. In the presence of Zn2+ ions, the NPs selectively show an obvious turn-on fluorescence change. This selective response of the NPs allows the determination and quantification of Zn2+ in human hair with a detection limit of 61.3 nM. This study demonstrates that the small molecule self-assembled nanoparticle is a versatile and useful tool, and shows great potential for applications in sensing of important analytes in biological systems. (C) 2016 Elsevier B.V. All rights reserved.
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