Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 704, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2019.135263
Keywords
Contamination; Dose-response relationship; Environmental pollution; Global environmental change; Hormesis; Stress biology
Categories
Funding
- National Natural Science Foundation of China (NSFC) [31950410547]
- Startup Foundation for Introducing Talent of Nanjing University of Information Science & Technology (NUIST), Nanjing, China [003080]
- US Air Force
- AFOSR [FA9550-13-1-0047]
- ExxonMobil Foundation [S18200000000256]
Ask authors/readers for more resources
The phrase what doesn't kill us makes us stronger suggests the possibility that living systems have evolved a spectrum of adaptive mechanisms resulting in a biological stress response strategy that enhances resilience in a targeted quantifiable manner for amplitude and duration. If so, what are its evolutionary foundations and impact on biological diversity? Substantial research demonstrates that numerous agents enhance biological performance and resilience at low doses in a manner described by the hormetic dose response, being inhibitory and/or harmful at higher doses. This Review assesses how environmental changes impact the spectrum and intensity of biological stresses, how they affect health, and how such knowledge may improve strategies in confronting global environmental change. (C) 2019 Elsevier B.V. All rights reserved.
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