Journal
BIOSENSORS & BIOELECTRONICS
Volume 77, Issue -, Pages 609-612Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.10.026
Keywords
Label-free detection; Iridium(III) complex; G-pentaplex; Cs+
Categories
Funding
- Hong Kong Baptist University [FRG2/14-15/004]
- Health and Medical Research Fund [HMRF/13121482, HMRF/14130522]
- Research Grants Council [HKBU/201811, HKBU/204612, HKBU/201913]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- National Natural Science Foundation of China [21575121]
- Guangdong Province Natural Science Foundation [2015A030313816]
- Hong Kong Baptist University Century Club Sponsorship Scheme
- Interdisciplinary Research Matching Scheme [RC-IRMS/14-15/06]
- State Key Laboratory of Synthetic Chemistry
- Science and Technology Development Fund
- Macao SAR [103/2012/A3, 098/2014/A2, 007/2014/AMJ]
- University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS]
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A series of 5 randomly designed in-house cyclometalated Ir(III) complexes were examined for their application in G-pentaplex probes and the proof-of-principle concept in G-pentaplex-based Cs+ ions detection. The G-pentaplex-forming sequence (DNA1, 5'-T(iG)(4)T-3', where iG=isoguanine) is present in single strand DNA form ab initio, however, the addition of Cs+ ions lead to formation of the intermolecular G-pentaplex structure which is identified by the novel Ir(III) complex 1 afterward and produce an enhanced luminescence signal for Cs+ ions monitoring. To the best of our knowledge, this is the first G-pentaplex probe and also the first G-pentaplex-based label-free detection platform for Cs+ ions reported in the literature. The monitoring of spiked Cs+ ions in natural water samples demonstrates the potential application and technical sound of this proof-of-principle concept sensing platform. (C) 2015 Elsevier B.V. All rights reserved.
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