Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 63, Issue 1, Pages 18-58Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-019-1572-7
Keywords
preimplantation; fetal germ cell; oogenesis; spermatogenesis; female infertility; male infertility; gene editing; single-cell sequencing
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Reproductive biology is a uniquely important topic since it is about germ cells, which are central for transmitting genetic information from generation to generation. In this review, we discuss recent advances in mammalian germ cell development, including preimplantation development, fetal germ cell development and postnatal development of oocytes and sperm. We also discuss the etiologies of female and male infertility and describe the emerging technologies for studying reproductive biology such as gene editing and single-cell technologies.
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