Journal
BIOSENSORS & BIOELECTRONICS
Volume 85, Issue -, Pages 743-750Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.05.083
Keywords
Colorimetric detection; Gold nanoparticles; Sialic acid; Aggregation; 4-mercaptophenylboronic acid
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Funding
- Royal Golden Jubilee Ph.D-program (RGJ) by The Thailand Research Fund [3.C.PS/51/B.1]
- Higher Education Research Promotion
- National Research University Project of Thailand, Office of the Higher Education Commission
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Office of the Higher Education Commission
- Trace Analysis and Biosensor Research Center (TAB-RC)
- Graduate School, Prince of Songkla University, Hat Yai, Thailand
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A simple and selective colorimetric sensor for sialic acid detection, based on the aggregation of 4-mercaptophenylboronic acid functionalized gold nanoparticles (4-MPBA-AuNPs) was developed. The color of the solution changed from wine-red to blue after binding with sialic acid. The colorimetric sensor provided good analytical performances with a linear dynamic range of 80 mu M to 2.00 mM and a 68 +/- 2 mu M limit of detection without any effect from possible interferences and sample matrix. In addition, the quantitative results were obtained within only 10 min. This developed sensor was used to detect sialic acid in blood serum samples and the results were in good agreement with those from the current periodate-resorcinol method (P>0.05) thus indicating that this developed colorimetric sensor can be used as an alternative method for sialic acid detection with a shorter analysis time and a high accuracy. (C) 2016 Elsevier B.V. All rights reserved.
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