Journal
SCIENCE
Volume 367, Issue 6474, Pages 205-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aau2753
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Funding
- Global Frontier Project of the National Research Foundation - Ministry of Science and ICT (MSIT) of Korea [NRF-M3A6A4-2010-0029785, NRF-2014M3A6A4075060, NRF-2015M3A6A4076702, NRF-2013M3A6A4044795]
- Korea Basic Science Institute [T39720]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [2018R1A6A1A03023718]
- National Research Council of Science & Technology (NST), Republic of Korea [C060200, T39720] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2013M3A6A4044795, 2015M3A6A4076702, 2014M3A6A4075060] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Despite the importance of glucose and amino acids for energy metabolism, interactions between the two nutrients are not well understood. We provide evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage. Upon glucose starvation, LARS1 was phosphorylated by Unc-51 like autophagy activating kinase 1 (ULKI) at the residues crucial for leucine binding. The phosphorylated LARS1 showed decreased leucine binding, which may inhibit protein synthesis and help save energy. Leucine that is not used for anabolic processes may be available for catabolic pathway energy generation. The LARSi-mediated changes in leucine utilization might help support cell survival under glucose deprivation. Thus, depending on glucose availability, LARS1 may help regulate whether leucine is used for protein synthesis or energy production.
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