Sulfonated magnetic nanocatalyst and application for synthesis of novel Spiro[acridine-9,5′-thiazole]-1,4′-dione derivatives

Sulfonated Sulfurol supported Fe3O4 (Fe3O4@SiO2-Pr-Sulfurol-SO3H) a new magnetic reusable nanocatalyst was prepared using chemical modification of magnetic nanoparticles (MNPs) surface with Sulfurol-SO3H. The Sulfurol-SO3H moieties on the surface of MNPs act as acidic catalytic sites for catalysis purposes. Fe3O4@SiO2-Pr-Sulfurol-SO3H was authenticated by usual analytical and spectroscopic techniques. The prepared Fe3O4@SiO2-Pr-Sulfurol-SO3H MNPs were applied to the preparation of novel Spiro[acridine-9,5 '-thiazole]-1,4 '-dione derivatives via the three-component condensation of isatins, dimedone and thioamides or thioureas.