Validation and extension of the gas-phase superacidity scale

Rationale In recent years it has become increasingly evident that the previously reported experimental gas-phase acidity (GA) values of several strong acids differ markedly from the corresponding high-level computational values. In this work, the superacidic part of the current gas-phase acidity scale was validated and extended. Methods For that, the strongly acidic section of the gas-phase acidity scale was remeasured using the equilibrium Fourier transform ion cyclotron resonance (FTICR-MS) method, adding new compounds and introducing methodological changes. In particular, a novel approach for anchoring the scale was used - the results were anchored to the computational (W1BD) GA values of trifluoromethanesulfonic acid and bis(fluorosulfonyl)imide (291.3 and 286.2 kcal mol(-1), respectively). Results The newly measured section consists of 20 gas-phase superacids and its consistency standard deviation is 0.2 kcal mol(-1), indicating good consistency. In contrast to the previously reported experimental gas-phase acidities for a number of important superacids, the current results are consistent with high-level theoretical GA values. Structure-acidity relationships based on the current results as well as available MeCN and DCE acidity data were described and explained. Conclusions The introduced methodological innovations were found to be adequate and strong evidence is presented in support of the current GA values of the strong acids.